Keeping alumni and friends connected to U-M

index_overeating_rat
Topics: Research News

Overeating linked to newly discovered brain mechanism

By Jared Wadley
.

 
Related: Target for Obesity Drugs Comes into Focus

A part of the brain usually thought to control movement also may cause people to overeat, say University of Michigan researchers.

A new study published in the journal Current Biology indicates that a new brain mechanism in the neostriatum produces intense motivation to overeat tasty foods.

The neostriatum, located near the middle and front of the brain, traditionally has been thought to control only motor movements. This is the part of the brain that is damaged in patients with Parkinson’s disease and Huntington’s disease. Yet for several years, it has been known that the neostriatum is active in brains of obese people when viewing or tasting foods, and in brains of drug addicts when viewing photos of drug-taking.

When U-M researchers gave extra morphine-like drug stimulation to the top of the neostriatum in rats, it caused the animals to eat twice the normal amount of sweet, fatty foods. (Image: Alexandra DiFeliceantonio)

When U-M researchers gave extra morphine-like drug stimulation to the top of the neostriatum in rats, it caused the animals to eat twice the normal amount of sweet, fatty foods. (Image: Alexandra DiFeliceantonio)

The research shows that an opium-like chemical called enkephalin, which is produced naturally in the brain, is a mechanism that generates intense motivation to consume pleasant rewards, says Alexandra DiFeliceantonio, a doctoral student in psychology and the study’s lead author.

When researchers gave extra morphine-like drug stimulation to the top of the neostriatum in rats, it caused the animals to eat twice the normal amount of sweet, fatty food. For this study, that food was M&Ms.

“The same brain area we tested here is active when obese people see foods and when drug addicts see drug scenes,” DiFeliceantonio says. “So it seems likely that our enkephalin findings in rats mean this neurotransmitter may drive some forms of overconsumption and addiction in people.”

Researchers measured levels of enkephalin using a painless microdialysis probe while rats were allowed to eat as much chocolate as they wanted. They found enkephalin levels surged dramatically as soon as the rats started to eat, and remained high as long as they ate.

In addition, when researchers gave a painless microinjection of an opioid-stimulating drug in the rats’ neostriatum, the rats ate double the amount of chocolate.

DiFeliceantonio and colleagues mapped where extra drug stimulation of opioid receptors affected eating habits. They found overeating was only caused in one region at the front and center part of the neostriatum.

“Finding the brain mechanisms for overconsumption is a step toward designing better biological-based treatments for obesity and binge eating disorders,” DiFeliceantonio says.

The study’s other researchers were Omar Mabrouk, a postdoctoral research fellow in pharmacology and chemistry; Robert Kennedy, the Hobart H. Willard Collegiate Professor of Chemistry and professor of pharmacology; and Kent Berridge, the James Olds Collegiate Professor of Psychology and Neuroscience.

Jared Wadley

Jared Wadley

JARED WADLEY writes about faculty research and student learning in departments mainly affiliated with U-M's College of Literature, Science, and the Arts, such as political science, psychology, communication studies, sociology and women's studies. Wadley joined the University in 2002 after spending 13 years as a business, retail, and economic development reporter at The Press-Enterprise (Calif.) and Flint Journal.

LEAVE A COMMENT: